Takashi Natsume, a boy who can see youkai, is followed by Natsume Yuujinchou San. Natsume and his bodyguard Madara, dubbed Nyanko-sensei, continue their mission through the "Book of Friends" to free youkai from their obligations. Natsume accepts his capacity to perceive youkai and no longer considers it a curse. He understands how much he likes his human and youkai pals as he spends more time with them both and concludes he doesn't have to choose between the spirit and human worlds to be happy.