Mushi, the ghostly, primeval entities, continue to produce strange alterations in the lives of mankind. Ginko, a traveling Mushishi, persists in attempting to correct the bizarre and uncomfortable events he finds. Overt impacts of Mushi influence include time loops, living shadows, and telepathy, but more subtle symptoms that take years to discover also cause Ginko anxiety as he travels from village to village. Ginko has become an arbitrator by circumstance, judging which Mushi are blessings and which are curses. However, the lines he wants to draw are subjective. Some of his patients would rather use their new abilities until they were completely devoured by them, while others feverishly want to rid themselves of illnesses that are really protecting them.