Doujin Work covers the story of a young girl called Najimi Osana and her introduction to the world of doujin. She was first enticed to become a doujin artist after witnessing how much one of her friends can earn at a conference. Najimi enjoys drawing, but she quickly discovers that, contrary to her expectations, this new world is far from easy. Najimi finally finds a group of highly intriguing pals as she attends more conventions and meets more individuals. These friends already have some experience in the field and help her out along the way so that she can someday make a name for herself creating doujinshi.