Hiroshi was assigned as the manager of his company's Mexico division in order to harvest the nectar from a new variety of cactus. As a result, the Nohara family packs their belongings and relocates to Mexico. They had to say sad goodbyes to their friends and the people of Kasukabe in tears. Shinnosuke is excited for this excursion after hearing that Mexican young females are trendy and gorgeous. When they arrive in Mardequellyovaca, Mexico, they face a new existence full of uncertainty, surrounded by unusual neighbors. Shinnosuke and the Nohara family, on the other hand, had no notion that flesh-eating deadly cactuses were on their way. To defend the village, the Nohara family and their neighbors join forces to combat "Killer Cactus."