3X3 Eyes tells the story of Yakumo Fuuji, a young man who becomes the immortal slave of the last of a race of 3 Eyed demons after a peculiar series of events. To save his life, the demon consumes his soul, making him eternal in the process. Now he embarks on a quest with the female demon in order to discover a way to become human. Of course, there are other obstacles along the road, not least of which is the fact that the demon is a girl with two personalities, one achingly cute and the other a no-nonsense destructive power, as well as the romances that grow between them.